IMRT

How to calculate cancer risks at high doses

1. Estimate the low dose (~2 Gy) age- gender- and organ-specific relative risks from A-bomb survivors 2. Use standard models to “ convert ” these low dose relative risks to apply to Western population / individual of given age and gender 3. Extrapolate these low-dose risks to fractionated high doses using mechanistic models (initiation / killing / repopulation)

Sachs&Brenner, PNAS 2005