IMRT

Foreword (2)

It is important to note that biological models aim to represent an extremely complex reality using simplistic equations and a small number of parameters. NTCP models summarize and formalize observations connecting normal tissue injury and dose-volume distributions (… clinical risk factors) NTCP models are mathematical/biophysical methods describing the probability that a certain percentage of the patient population will exhibit (unfavourable) reactions in healthy tissues. NTCP is calculated from the (non- uniform) dose distribution throughout the organ of interest by using the DVH (at least for the current models)

ENDPOINT DEFINITION DOSE-VOLUME DATA PATIENT RELATED DATA