IMRT

Mechanistic modelling • Empirical models are statistical tools enabling the treatment planner to use clinical experience efficiently. – Assume a black box between input (dose distribution) and output (outcome) – Based on DVHs; ignore internal organ substructures and variation in response across the organ. • Attempts have been made to develop more mechanistic models of normal tissue response. – The outcome is modelled as a consequence of mechanisms in the normal tissue triggered by radiation. – Parameter values from experiments, assays of tissue function and simulations