IMRT

Eisbruch et al, IJROBP 45, 3:577, 1999 Prospective study • 51 patients, parotid sparing bilateral neck RT (advanced head & neck)

37 patients, unilateral neck RT (small lateral tumors) • Saliva flow rates measured before and 1 year after RT • Threshold mean dose to the glands for suppression of the salivary flow: 24 - 26 Gy Roesink et al, IJROBP 51, 4:938, 2001 Prospective study • 180 patients, 174 parotid glands • Saliva flow rates measured before and after RT (6 weeks, 6 months, 1 year) • Postradiotherapy saliva flow decreased with increasing irradiated volume to a mean dose between 35 and 45 • No threshold mean dose