Image-Guided Radiotherapy and Chemotherapy in Gynaecological Cancer

Institutional series >100 patients ”radiographic-era”

Author (ref) acrual period

Vaginal recurrence

Locoregional recurrence

No. patients, eligibility

Treatment

Survival

Severe complications

Institutional series including at least 100 patients

Sorbe et al. 35

404; Stage I

0,7% 3,0% 92% OS at 5-years 6.9% significant

publ 1990 MacLeod et al. 31 141; Stage I-IIIA 4 x 8.5 Gy at surface

1,4% 2,0% 91% OS at 5-years no grade 3/4

1985-1993 Weiss et al. 36

122; Stage I-II

3 x 7 Gy at surface

1,6% 4,1% 94% NED at 5-years no grade 3/4

1987-1993 Eltabbakh et al. 28 332; Stage IA grd 1-2 1 x 30 Gy LDR at surface 0,0% 0,6% 99% DFS at 5-years 2.1% grade 3/4 1958-1994 Petereit et al. 32 191; Stage IA grd 1-2 2 x 16.2 Gy at surface 0,0% 0,5% 95% OS at 5-years 0.5% grade 4 1989-1997 ovoids Anderson et al. 26 102; Stage I 3 x 5 Gy at 0.5 cm 1,0% 1,9% 84% OS at 5-years no grade 3/4 1990-1996 Horowitz et al. 29 164; Stage I-II 3 x 7Gy at 0.5 cm 1,2% 0,6% 87% OS at 5-years no grade 3/4 1989-1999 Alektiar et al. 25 382; Stage I-II 3 x 7Gy at 0.5 cm 0,8% 0,0% 93% OS at 5-years 0.5% grd 3/0.3% grd 4 1987-2002 Solhjem et al. 33 100; Stage I grd 2-3 and3 x 7Gy at 0.5 cm 0,0% 0,0% 98% OS at 3-years no grade 3/4 1998-2004 IB grd 1-2 if >2cm Ataham et al. 27 128; Stage I 5 x 5.5 Gy at 0.5 cm 0,0% 1,6% 96% OS at 5-years no grade 3/4 1994-2005 • Different: dose/fractionation & prescription • Different applicators: most cylinder, but also ovoid, ring, mould