Image-Guided Radiotherapy and Chemotherapy in Gynaecological Cancer

Evidence that OAR do not like dose

PORTEC-1: Patient reported bowel symptoms 15-years after 46Gy

EORTC need to get to toilet in time BS

EORTC limitation daily activities due to BS

100%

100%

90%

90%

80%

80%

70%

70%

very much quite a bit a little not at all

very much quite a bit a little not at all

60%

60%

50%

50%

40%

40%

30%

30%

20%

20%

10%

10%

0%

0%

EBRT

NAT

EBRT

NAT

EORTC Fecal Leakage

EORTC Diarrea

100%

100%

90%

90%

80%

80%

70%

70%

very much quite a bit a little not at all

very much quite a bit a little not at all

60%

60%

50%

50%

40%

40%

30%

30%

20%

20%

10%

10%

0%

0%

EBRT

NAT

EBRT

NAT

Nout et al, JCO 2011