Image-Guided Radiotherapy and Chemotherapy in Gynaecological Cancer

New MRI technologies

• Dynamic Contrast Enhanced (DCE) MRI

• Diffusion-weighted imaging (DWI)

• Blood oxygen level dependent (BOLD) MRI

• Proton spectroscopy

From: Harry VN. Gynecol Oncol 2010

Measuring kinetic profile

Tumor extracellular space

Modelling tumour perfusion

Transfer Constant - K trans

Efflux to plasma - K ep

DCE MRI

Bolus i.v. Gd contrast

Tumor neovascularity

V of extracellular space

Extravascular leakage space

Review: Lee SI, et al. JNM 2015;56(3). Harry VN. Gynecol Oncol 2010