Imaging for early stage breast cancer

Doing a GWAS is fishing in the ocean of trait associated SNPs

Sample size

Genotype Relative Risk

10 0

GRR=2.00 GRR=1.50

1000

GRR=1.25

10000

GRR=1.10

GRR=1.05

10000 0

0

0.1 0.2 0.3 0.4 0.5

Risk allele frequency

Andreassen CN et al., Cancer Letters 2016