Imaging for early stage breast cancer

Fat necrosis

Incidence of fat necrosis in various series of APBI using high dose rate brachytherapy

Center (Author) ref

No. of

Brachytherapy

Method of detection of fat

Incidence of

Time of detection

Location of fat

Additional

Median follow

Factors affecting

patients

necrosis

Fat necrosis

of fat necrosis

necrosis

investigations

up (months)

fat necrosis

(months)

National institute of Oncology

87

HDR 36.4Gy

Clinical, mammography,

17

Tumor bed-

47%

48

Bra cup size

36.5%

Lovey et al..

pathology

84.2%

Tufts/Brown University, Wazer et

33

HDR 34Gy

Clinical,

7.5

Tumor bed-100%

62%

33

Volume of 150 and

24%

al.

mammography,pathology

200%, no of dwell

positions

National Institute of oncology,

45

HDR 30.3Gy,

MammogramClinical,

-

-

2.2%(surgery)

81

-

22%

Polgar et al.

36.4Gy

pathology

London Regional Cancer Center,

39

HDR 37.2Gy

Clinical pathology

Within 60

-

91

-

13%

Perera F et al.

Virginia Commonwealth

31

HDR 34Gy

Mammogramclinical

-

-

0

42

-

2%

University, Arthur DW et al.

University Hospital Earlangen,

33

HDR/PDR

Mammogram

25.6

-

0

60

-

15%

Ott OJ et al.

William Beaumont Hospital,

79

HDR 32Gy, 34Gy

Mammogram clinical

66

-

7.3% (surgery)

60

-

11

Vicini et al, Chen Y et al.

Present study

171

HDR 34Gy

Clinical, mammography,

24

Tumor bed 100% 45%(biopsy,excisi

48

Volume of

18%

pathology

on biopsy)

excision

University Hospital Erlangen

Budrukkar et al. Fat necrosis in women with early-stage breast cancer treated with accelerated partial breast irradiation (APBI) using interstitial brachytherapy; Radiotherapy and Oncology 103