Imaging for early stage breast cancer

Long-term outcomes of proton beam RT, Study from Massachusetts General Hospital, Boston

Phase I study N=98 patients stage 1 2003-2006 3D CRT 32 Gy / 8 fr / 4 days 19 treated with protons, 79 treated with photons Median FU 82.5 months

PTV was lumpectomy cavity +15 to 20 mm inside breast PTV volume recommended to be less than 30-35% of the breast Non-target breast preferred to receive no more than 50% of prescribed dose Details for protons: 1-3 fields, 1 field treated per day owing to availability of proton maschine Passive scattered technique Delivered physical dose adjusted to account for higher RBE of protons compared to photons

Galland-Girodet et al, IJROBP 2014