Imaging for early stage breast cancer

Accelerated Partial Breast Irradiation – ready for prime time

Breast-conserving surgery + EBRT trials: 7300 pts.

APBI trials using EBRT or BT: ~10.000 pts.

Trial

Participants Technique

n

Study period

Budapest

Hungary

HDR iBT, é

258

1998-2004

TARGIT

Multicentric

IORT 50kV

2232

2000-2009

ELIOT

Milano

IORT - é

1306

2000-2007

GEC-ESTRO Europe,

HDR-/PDR- iBT

1184

2004-2009

multicentric

RAPID

Canada, multicentric

3D-CRT

2128

2006-2011

NSABP-B39/ RTOG-0413

USA, multicentric

3D-RT, HDR-iBT

~4300

2005-2013

Florence

Italy

IMRT

520

2005-2013

Hypofractionation trials: START A: 2236 pts. Royal Marsden Hospital: 1410 pts. START B: 2215 pts. ~5861 pts.

Barcelona

Spain

3D-CRT

102

2007-2010

IMPORT- LOW

UK, multicentric

IMRT

1935

2006-2011

~14.000

University Hospital Erlangen