In-room imaging and MR planning

Results: local control & survival

Group Year N Dose rate Interstitial BT (%)

LC

OS Grade 3- 4 tox

Vienna 2011 156 HDR

44% 95% at 3 yrs 43% 91% at 3 yrs

68% at 3 yrs 79% at 3 yrs 88% at 2 yrs 76% at 3 yrs 65% at 5 yrs 74% at 3 yrs

6%

Aarhus

2013 140 PDR

7%

Pittsburg 2014 128 HDR

0%

92% at 2 yrs 86% at 3 yrs

1%

Paris

2015 225 PDR

2%

7%

Leuven 2016 154 PDR

16% 96% at 3 yrs 23% 91% at 3 yrs

11%

Retro- EMBRACE

2016 731 mixed

11%

Conclusion: 86 – 96% local control at 2 – 3 years, with severe late toxicity ≤ 10%