In-room imaging and MR planning

Several “focal boosting” trials

FLAME

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– Utrecht – van Vulpen & van der Heide, Ph3 RCT vs. 77Gy/35 fractions

IB 95Gy/35 fractions

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N=566

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DCE- and DW-MRI

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Endpoint – BNED

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HEIGHT

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Miami – Pollack, Ph2 RCT vs. 80Gy

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– CTV 76Gy, GTV 90 Gy IB (in 38 fractions)

N=72

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DCE-MRI only

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Endpoint – biopsy at 2 years

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TARGET

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– Princess Margaret – Menard, Ph2 (case-control)

– CTV 76Gy, GTV 95Gy IB (in 38 fractions)

DWI + T2 (+ DCE)

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N=80

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Endpoint – biopsy at 3 years

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Slide courtesy of C. Menard.