Lower GI 2016

SCC of the Anal Margin

• 5 – 10x less common than anal canal tumours • more often well differentiated & keratinizing • less often hrHPV positive ( 80% in women & 28% in men – Frisch et al 1999 ) • Small well differentiated tumours < 2cm can be treated by local excision +/- adjuvant radiotherapy • Larger tumours that are poorly differentiated or metastatic to inguinal lymph nodes ( 15 – 20 % of patients ) are treated with radiotherapy or CRT