Lower GI 2016
ADXS11-001 immunotherapy
• live attenuated Listeria monocytogenes (Lm) • bioengineered to secrete a HPV-16-E7 fusion protein targeting HPV transformed cells.
• Anal cancer cells infected with HPV have the tumour associated antigen HPV E7.
• So ADXS11-001 causes antigen presenting cells to be stimulated to facilitate immune cells to attach to cancer cells expressing HPV E7
• neutralizes Tregs and myeloid-derived suppressor cells (MDSCs), which protect the tumour microenvironment from immunologic recognition and contribute to tumour growth .
Made with FlippingBook