Lower GI 2016

Polish Trial II

50.4 Gy 5-FU/Ox

5x5 Gy FOLFOX

P-value

Number of pts

254

261

R0 resection (%)

71

77

.07

12

16

.21

pCR (%)

Acute tox grade 1+2/ 3+4 / 5

50 / 21 / 3

60/ 23 / 1

.006

Postop complication

25

29

.18

Local Failure @3y (%)

21

22

.82

Disease-free Survival @ 3y (%)

52

53

.85

Med. F/u: 35 mo

Overall Survival @ 3y (%)

65

73

.046

Bujko et al., ASCO GI 2016