Lower GI 2016

Anal Cancer : the importance of tumour size

• Das et al ( 2007 ) : 167 patients treated with CRT

3 yr locoregional control : T1/Tx 90 % ( 76 – 100 ) T2 86 % ( 76 – 96 ) T3 77 % ( 61 – 93 ) T4 63 % ( 41 – 86 )

T stage a significant independent predictor of loco-regional failure on multivariate analysis ( HR 1.71 )

• Ajani et al ( 2009 & 2010 ) : RTOG 98-11 trial of RT + 5FU/MMC versus RT + 5FU/cisplatin • Tumour diameter > 5cm associated with a greater risk of colostomy, worse 5 yr DFS & 5 yr OS ( p = 0.0003 ) compared with smaller tumours