Lower GI 2016

ANAL CARCINOMA : HISTOLOGICAL CLASSIFICATION

• SQUAMOUS CELL CARCINOMA NOS ( 80 - 90% ) size of neoplastic cell basaloid morphology keratinization presence of mucinous microcysts WHO 2 nd Edition. large cell keratinizing large cell non-keratinizing Basaloid ( cloacogenic )

degree of differentiation presence of adjacent AIN

• VERRUCOUS CARCINOMA ( GIANT CONDYLOMA OF BUSCHKE-LOWENSTEIN ) ( < 1 % )

• ADENOCARCINOMA ( anal gland, mucinous – fistula related, rectal type )

( 10 – 15 % )

• NEUROENDOCRINE CARCINOMA ( large cell & small cell type ) ( < 2 % )