Lower GI 2016

study

No. Time period treatment outcome

Boman et al ( 1984 ) SCC – grades 1 to 4 Basaloid type SCC

188 1950-1976 Surgery

Grade & type correlated with stage. No significant correlation with survival after adjusting for stage. No correlation of histologic type with depth of invasion or node metastasis. No correlation with survival.

Dougherty et al ( 1984 ) Keratinizing SCC Non-keratinizing SCC Basaloid SCC SCC with microcysts Shepherd et al (1989) SCC Basaloid type Bartelink et al (1997) SCC versus other types Histologic grade Myerson et al (2001) SCC – low & high grade Basaloid type Mixed type

79 Pre 1978 Surgery

235 1948-1985 Surgery

Histologic type not predictive of survival in multivariate analysis.

110 1987-1994 RT & CRT

Neither type nor grade predicted local control or survival.

106 1975-1997 Mainly CRT

Borderline significant improved 5yr DFS for basaloid type. No effect of tumour grade. Basaloid type associated increased risk of Distant Metastasis (HR 4.23) . No correlation type or grade with loco-regional failure or survival.

Das et al (2007) SCC grades 1 to 3 Basaloid type

167 1992-2004 CRT