Lower GI 2016

Biomarkers in anal Carcinoma – Much Ado About Nothing

• BCL – 2 : 3 studies 2003 – 2009 ( n = 21 – 98 )

immunohistochemistry in all 3 studies BCL 2 expressed in 24 – 58 % of cancers associated with reduced local control and DFS in one study ; no prognostic significance in the other two • Ki67 : 4 studies 1998 – 2009 ( n = 31 – 62 ) Immunohistochemistry ( MIB1 ) used in all studies No prognostic significance in 2 out of 4 studies ; elevated Ki67 associated with longer DFS in one study and improved colectomy free survival in a second study.

Others : VEGF - no prognostic significance MVD - no prognostic significance PCNA - no prognostic significance

Cyclins - no prognostic significance in 3 out of 4 studies

( Lampejo et al 2010 )