Lower GI 2017

Prognostic relevance of TILs

Patients (n)

Results

Author

38

Grabenbauer

CD3/CD4: decreased 3 years NED

277

Rubio

CD3/CD8: increased 15 years survival

intratumoral CD8: increased DFS

40

Hu

peritumoral CD8: increased OS

153

Gilbert

increased relapse-free survival

High levels of TILs, especially CD8(+) cells, are associated with a favourable clinical response and survival

Grabenbauer G, Clin Cancer Res 2006; Rubio C, Int J Clin Exp Pathol 2008; Hu W, J Surg Oncol. 2015; Gilbert DC, Br J Cancer 2016