Lower GI 2017

PLATO - PersonaLising Anal cancer RadioTherapy dOse

T1 N0 Anal margin

T3/4 Nany,T2N2-3

T1,T2<4cm N0

Local excision

ACT5

ACT4

ACT3

58.8Gy 28F

61.6Gy 28F

53.2Gy 28F

Pilot

Margin ≤1mm

41.4Gy 23F

50.4Gy 28F

Ph II

41.4Gy 23F

Obs n

Randomised 2:1 Phase II trial N=162

Phase II trial N=90

Ph III

Pilot/Ph II/PhIII N=677

Primary end point :- 3yr locoregional failure