Lower GI 2017

The Royal Marsden

1958 – to present

• Jass (St Marks, UK) : increasing depth of spread – independent prognostic significance • Harrison (Tennessee, USA): prognostic score use depth of spread in mm • Cawthorne (Guildford, UK): depth of spread significance • Merkel and Hermanek (Erlangen, Germany) : T3 subclassification • T3a <1mm • T3b>1-5mm, • T3c>5-15mm • T3d>15mm (TNM staging system 1993 supplement) Extramural depth of spread is an equally important prognostic factor as node status