Lower GI 2017

The Royal Marsden

Enrolment mrTRG1 -2 @4-6 weeks post CRT no viable disease (low signal intensity fibrotic scar tissue only) confirmed by MRI @ 8-12 weeks

mrTRG3 @ 4-6 weeks post CRT a good partial response Continued incremental response on MRI @ 8-12 weeks

NOT INITIALLY EXCLUDED EVEN IF: DRE - Thickening of rectal wall or clinically palpable tumour Endoscopically – mucosal abnormality Pathology - Biopsy positive