Lower GI 2017

The Royal Marsden Objectives of trial

– recruit patients and stratify treatment using mrTRG directed management. The ‘good responders’ (mrTRG1&2) often have no evidence of tumour and it may be possible to avoid surgery in this group (deferral of surgery). – The ‘poor responders’ (mrTRG3-5) are at high risk of poor oncological outcomes and additional therapy before surgery may improve prognosis.