Lower GI 2017

pCR after CRT for LARC – Evidence for a Better Outcome. • Maas et al ( 2010 ) : pooled analysis of 3105 patients undergoing surgery after CRT for LARC ( 17 datasets ; 27 published articles ) pCR – 484/3105: 16 % median follow-up : 48 months ( 0 – 277 )

5 yr crude DFS : pCR

83.3 % 65.6 %

non-pCR

• Adjusted HRs after multivariate analysis: DFS

0.54 ( 0.4 – 0.73 ) 0.41 ( 0.21 – 0.81 ) 0.49 ( 0.34 – 0.71 ) 0.65 ( 0.47 – 0.89 )

Local recurrence

Distant metastasis free survival

OS