Lower GI 2017

TRG , ypT & ypN stage

• 131 resectable cT3/T4 rectal carcinomas treated with CRT ( polish RCT of SCRT versus pre-op CRT )

TRG 0 : no cancer cells present TRG 1 : a few cancer foci ( < 10% of tumor mass )

TRG 2 : residual cancer representing 10 – 50 % of tumor mass TRG 3 : residual cancer representing > 50 % of tumor mass

ypT0

ypT1

ypT2

ypT3

ypN0

ypN1/2

TRG 0 22 ( 100% )

20 ( 95% )

1 ( 5 % )

TRG 1

7 ( 17% )

25 ( 63 % )

8 ( 20 % )

31 ( 77 % )

9 ( 23 % )

TRG 2

1 ( 3 % )

13 ( 32 % )

26 ( 65 % )

22 ( 55 % )

18 ( 45 % )

TRG 3

4 ( 14 % )

10 ( 34 % ) 15 ( 52 % )

15 ( 54 % )

13 ( 46 % )

ypT stage best predictor of nodal status in multivariate analysis : OR 4.66 for ypT2 & 12.06 for ypT3 versus ypT0/1.

( Bujko et al 2010 )