Lower GI 2017

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Hyperfractionation

RTOG 00-12 hyperfractionated CRT did not improve

the rate of pathologic complete response or any clinical outcome (LC, DFS, OS)

Mohiuddin M, et al. Neoadjuvant chemoradiation for distal rectal cancer: 5-year updated results of a randomized phase 2 study of neoadjuvant combined modality chemoradiation for distal rectal cancer. Int J Radiat Oncol Biol Phys 2013: 86:523–528

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