Lower GI 2017

3. HDR-EBT – Boost after EBRT

- A dose-escalation phase III trial comparing 2 doses of radiation:

50,4 Gy in 28 fractions (n = 123) 50,4 Gy in 28 fractions + HDR-EBT boost 10 Gy in 2 fractions (n = 120)

- Both arms concomitant chemotherapy

- Primary endpoint: pCR - Secondary endpoints: Tumor response

Rate of complete resection

Jakobsen et al. Int J Radiat Oncol Biol Phys;84(4):949–54.