Lower GI 2017

Acute SB Toxicity: pathogenesis

DAMAGE

Distortion of the villous enzymatic deficit decreased capability to digest macromolecules in the intestinal lumen

Accumulation of glucides e peptons retains osmotically fluids in the bowel lumen. Osmotic DIARRHEA

ADSORPTION

Increase of organic residues with ph reduction adsorbtion of electrolites, gas production, endotoxin secretion. METHEORISM, CRAMPS, PAIN

reduced

Increase of the intraluminal fats decreased absorption of biliary salts Direct mucolytic action, increased cellular permeability and sodium trasudation Hyperperistaltism Reduction of the transit time Increased pathogenic bacterial. Aqueous DIARRHEA

SYMPTOMS

loss of appetite, weight loss, electrolyte imbalance…