Lower GI 2017

Late SB Toxicity: pathogenesis and symptoms

DAMAGE

Ischemia

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Intestinal wall edema

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Vascular degeneration (endoarteritis) Collagen production/deposition Damage of the lymphatic vessels

Mucosal ulcer

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Intestinal wall necrosis

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Hemorrages

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Strictures/Stenosis

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Adherences

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SYMPTOMS

• Intestinal transit alterations: PAIN and CRAMPS

Alternating STIPSIS and DIARRHEA

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• Maladsorption syndrome, FOOD INTOLEREANCE

Bleeding and anemia

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Sub-mucosal fibrosis, atipical fibrobasts, inflammatory infiltration, increased size of the endotelial cells