Lower GI 2017

Acute Proctitis: therapy

Topic steroids RESOLUTION of ACUTE SYMPTOMS (burning, pain, mucous…)

Mesalazine (5-ASA) oral 3/day + topical 1/day

REDUCTION of hemorragic proctitis, NO ACTION on pain, tenesmus or frequency of defecation

Sucralphate: Sucrose sulfate-aluminium complex that binds to the ulcer, creating a

physical barriers

ACTIVE in chronic proctitis small /no EFFECT in ACUTE proctitis

Sodium Butyrate : short chain fatty acid, produced by colon bacteria, increasing blood flow and mucosal integrity

small EFFECT vs PLACEBO in ACUTE PROCTITIS

Gibson RJ et al. Supp Cancer Care 2013