Lower GI 2017

IMRT & GI toxicity

- But….negative report from a controlled trial - NRG Oncology RTOG0822 study (IMRT to decrease acute GI tox 45Gy + boost 5.4Gy concomitant with Capecitabine/Oxaliplatin) - Sampled to detect ≥12% reduction of acute grade 2-5 CTC_AEv.3.0 compared to RTOG0247

- Rate 51 % vs 40% (RTOG0247) vs 28% (provisional) - Rate grade 3 diarrhea similar to studies using 3DCRT

Hong 2015