Lower GI 2017

ART optimization based on early response ?

- Analyses of MRI-based T regression correlated with pCR

- May Mid-RT MRI (average volume reduction: -56%) predict the pathological response ? - A poisson-based radiobiological model, incorporating the individual early response, well predicts pCR and residual cells (Raso, ESTRO 2016) - Potentials for selection of pts for ART and adaptation of boost dose (work in progress…)

TCP D =(1- ∆ V D ) V_PRE

AUC: 0.87 (specificity: 71.4%, sensitivity: 96.4%) (not lower discriminative power compared to post_RT MRI, AUC:0.82 n.s.); n=42 pts