Lower GI 2017

NSAPB R-04

RT 50.4 Gy 5-FU or Cape

RT 50.4 Gy 5-FU/Cape+Ox

P-value

Number of pts

636

640

pCR (%)

17.8

19.5

.42

▲

Grade 3/4 Tox

▼

Compliance to CRT

O‘Connell et al., J Clin Oncol 2014

.21 HR 0.71 .34 HR 0.91

Local Relapse after R0 @3y (%)

5.1

3.1

69.2 △ 5%

Disease-free Survival @ 5y (%)

64.2

Allegra et al., J Natl Cancer Inst 2015