Lower GI 2017

5 Options for chemotherapy in locally advanced rectal cancer

• Induction

- pre RT (Short-course(SCPRT) or

chemoradiation (CRT)( Expert, Expert C, Fernandez-Martos, Contre ) • Concurrent - With RT (CRT) (but NB toxicity) (5 oxaliplatin trials,1 irinotecan trial) • Consolidation - post CRT or SCPRT if waiting 6 12 weeks before surgery (Garcia-Aguilar, Polish , RAPIDO –Nordic Countries/Holland) • NACT alone Without radiation (Prospect, Bacchus ) •