Lower GI 2017

US Prospect Alliance Intergroup phase III trial ACOSOG, Z9062, CALGB, E81001

5FU CRT

LARC st II/III

FOLFOX #8

T

M

R

R0?

PR/SD ?

MRI: CRM -ve

E

FOLFOX #6

FOLFOX #6

R1/2?

PD?

5FU CRT

5FU CRT

N planned: 1010 1 ° endpoint: 3y DFS 2 ° toxicity, local failures, OS,