Lower GI 2017

Conclusions 1. 5FU-based CRT (45-50Gy) more effective (downsizing) than RT but no improvement in SpS, DFS or OS 2. Capecitabine is an equivalent option 3. Watch and wait remains experimental 4. Radio-sensitizing 5FU-based CRT not improved by additional oxaliplatin ? 5. Biologicals have not yet delivered 6. Postop adjuvant chemotherapy after SCPRT or CRT remains of unproven benefit