Modern Bt Techniques - Florence 2016

Inverse Optimisation and Planning

General Form of a Dose Objective Function

d i

j is the dose at the j th -sampling point for the i th -objective function: ∑ ∑ k N N ~ = = = cath ASDP k l i jkl lk i j dx d 1 1 2 (x)

Catheters Active SDPs Dwell time t lk

• x²

= t lk to avoid negative (non-physical) dwell time values t lk

lk

• can (should) be calculated in a pre-process step and are then available in a sense of a Look-Up-Table for the optimisation process. Implementations in this way (HIPO) make optimiser independent of the dose calculation engine considered (TG 43, MC-LUTs, CC, other Solvers) i jkl d ~