Molecular Imaging 2017

Immune Response Criteria

iRC: Bidimensional; Max 5/organ; Up to 10 visceral & 5 cutaneous lesions

CR

PR

SD

PD

Resolution of target lesions & all nodes <10 mm in short axis

>50% decrease from baseline

Neither PR not PD ≥25% increase from the nadir

iRC: Unidimensional simulating RECIST 1.1; Max 2/organ & 5 total

CR

PR

SD

PD

Resolution of target lesions & all nodes <10 mm in short axis

>30% decrease from baseline

Neither PR not PD ≥20% increase from the nadir

New lesions do not define progression & measurements are included in TL; PD or PR must be confirmed by 2 consecutive observations >4wks apart

Wolchok JD et al. Clin Cancer Res 2009;15(23):7412–20 Nishino M et al. Eur J Radiol 2015; 84: 1259–1268