Molecular Imaging 2017

High Grade Gliomas

RANO criteria

 Post contrast T1W: >10mm  Bidimensional measurement excluding cystic cavity  PR: >50% decrease in enhancing lesions; stable/improved non- enhancing T2/flair lesions  PD: >25% increase in enhancing lesions; increase in non-enhancing T2/flair lesions; new lesions

 Response classification:  Complete remission (CR)  Partial remission (PR)  Stable disease (SD)  Progressive disease (PD)

Wen et al. J Clin Oncol 2010; 28: 1963-72