Molecular Imaging 2017

Phase I/II trials

Vascular Response Assessment

Effects measured by T1 DCE-MRI

Therapy

Measured effect

Chemotherapy

IAUGC, K trans

Radiation

IAUGC, K trans initially, then

IAUGC, K trans initially, then

Anti-angiogenic agents

Ablative therapy IAUGC, K trans IAUGC = Initial area under the Gadolinium curve; K trans = transfer constant

Extent of changes depends on therapy evaluated & timing to therapy