Molecular Imaging 2017

Diffusion Response Markers

 Diffusion MRI used in >60 therapy studies  Therapy effects:  Decrease in high b- value signal intensity  Increase in tumour ADC ≥30%  Early response (14d) assessment achievable

ADC: 0.74 to 1.05 x10 -3 mm 2 /s

Afaq A et al. Cancer Imaging 2010; 10: S179-188; Bains LJ et al. Cancer Imaging 2012; 12:395-402