Molecular Imaging 2017

Clinical Implementation of DPBN: Prescription function • Dose prescription is different in each tumor voxel • Prescription function has to be integrated into the optimisation process during RT-planning linear sigmoid Dose Escalation Factor

PET voxel activity

SUV A [Bq/ml] 3.3 3585

84.0 Gy

80.5 Gy

77.0 Gy

2.6

2820

73.5 Gy

66.5 Gy

57.5 Gy

1.9

2060

51.5 Gy

42.0 Gy

28.0 Gy

1.2

1300