Molecular Imaging 2017

MR spectroscopy value for RT ? Results from imaging performed in a prospective trial

Metabolic maps of CHO/NAA >2

Before RT

100%

at 4 months

90%

80%

70%

60%

other

50%

T1CE with CNR2 at relapse

40%

30%

20%

10%

6 months later 0%

T1CE with CNR2 before RT T1CE with normal CNR before RT

Metabolically active voxel, no radionecrosis Statistically significant pronostic value compared with conventional imaging 80% of voxels with new contrast enhancing lesions were cho/NAA>2 before RT versus 20% of voxels with new contrast enhancing lesions were cho/NAA<2 MR spectroscopic imaging for dose-painting Laprie et al, IJROBP 2008