Molecular Imaging 2017

Predictive value of MR spectroscopy lactate/Naa ratio ?

Deviers et al, IJROBP 2014

Surrogate of tumor hypoxia

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• 4 millions voxels analysed, data from previous trial Zarnestra • Definition of a significant threshold of Lactates/NAA > 0.4 using ROC curves • Statistically significant predictivity for relapse – 71% of voxels with LNR0,4 are contrast enhancing at relapse vs 10% with LNR<0,4. • tendency for EFS

MR spectroscopic imaging for dose-painting

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