Molecular Imaging 2017

FDG-PET/CT in response assessment

High sensitivity (92%) and high negative predictive value (96.4%)

Pre-treatment FDG-PET/CT shows the anal tumor on axial slices (A). Corresponding images, obtained on post-treatment FDG- PET/CT performed 3 months after chemoradiotherapy (B), show low FDG uptake (complete metabolic response). At the end of follow-up the patient was alive and without evidence of recurrence.

Example of Complete Metabolic Response

Pre-treatment FDG-PET/CT shows the anal tumor on axial slices and shows a left inguinal node (white arrow) (A). Corresponding images, obtained on post- treatment FDG-PET/CT show persistent increased FDG uptake in anal canal (considered as non complete response), but complete regression of inguinal node uptake. Persistent disease was proven by biopsyed 4 months after chemoradiotherapy (B),

Example of partial metabolic response

Houard et al . JNM 2017