Molecular Imaging 2017

Validation of segmentation algorithms is crucial 1. Histopathology (gold standard) • Difficult to assess. • Changes in volume and orientation may be challenging 2. Validation with phantom measurements • Necessary to have • Real tumours are often not spherical • Cannot substitue validation with pathology 3. Comparison to manual delineations • Intra-observer variations • Regularized auto-segmentation method may always yield similar accuracy