Molecular Imaging 2017

P rostate- S pecific M embrane A ntigen ( PSMA )

• PSMA,

also known as

Glutamate

carboxypeptidase II , is a type II transmembrane glycoprotein (Upon ligand binding PSMA is internalized with bound molecules) • PSMA is expressed in a number of tissues including prostate, kidney, and both the central and peripheral nervous systems. • PSMA is an established cancer marker. In particular, it is upregulated in prostate cancer and has proven to be an effective diagnostic and prognostic indicator of cancer. • Ideal for developing targeted radiopharmaceuticals (fast blood clearance and low background activity)