Palliative care 2016

Pathofysiology of bone metastases

Local mechanisms of bone pain

Release of chemical mediators

•

• Increased pressure within the bone • Micro fractures • Stretching of the periosteum • Nerve root infiltration • Compression of the nerves due to collapse of the bone

(Jimenez et al, 2010)

(Vakaet et al, 2009)